MangoGen has data to clearly demonstrate that baculoviruses can deliver human genes to cells in culture, and when coated onto a device placed in vivo. For example, placing a baculoviral coated stent in a canine damaged femoral artery model the results clearly demonstrates the following:

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1) Released and enter the local cells (GENE-DELIVERY)

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2) Deliver human gene (e.g. VEGF)

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3) Gene is expressed and a functional growth factor is locally expressed (GREEN FLOURESCENCE)

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4) The gene is expressed TRANSIENTLY

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5) Accelerated Wound Repair (observed after 2 weeks)

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6) Positive benefits (wound healing) after 16 weeks, including:

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a) Reduced hyperplasia

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b) Significant reduction In-Stent Restenosis

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c) Improved blood flow

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