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Key Data
MangoGen has data to clearly demonstrate that baculoviruses can deliver human genes to cells in culture, and when coated onto a device placed in vivo. For example, placing a baculoviral coated stent in a canine damaged femoral artery model the results clearly demonstrates the following:
1) Released and enter the local cells (GENE-DELIVERY)
2) Deliver human gene (e.g. VEGF)
3) Gene is expressed and a functional growth factor is locally expressed (GREEN FLOURESCENCE)
4) The gene is expressed TRANSIENTLY
5) Accelerated Wound Repair (observed after 2 weeks)
6) Positive benefits (wound healing) after 16 weeks, including:
a) Reduced hyperplasia
b) Significant reduction In-Stent Restenosis
c) Improved blood flow

Delivered gene expression around
the proximity of the deployed stent.
After 16 weeks there was a significant
reduction of in-stent restenosis in blood
vessels treated with Vegf-delivered
baculoviruses.

Paul et al, (2013) Bioactive baculovirus nanohybrids for stent based rapid re-endothelialization
Nature Scientific Reports 3, 2366 READ MORE
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